Programme
12:30 - 13:30
Registration
13:30 - 13:45
Welcome & Opening
Katja Schenke-Layland, Vice-President for Research, University of Tübingen
13:45 - 15:35
Session 1: Neurodevelopment
13:45 - 14:35 Keynote 1: Jürgen Knoblich (Vienna, Austria)
Cerebral Organoids: Growing human brain tissue from stem cells to study development and disease
14:35 - 14:55 T01: Oleg Vinogradov (University of Tübingen, Germany)
Rescuing hyperexcitable network activity in hiPSC model of CACNA1E-related developmental and epileptic encephalopathy
14:55 - 15:15 T02: Cesar Mateo Bastidas Betancourt (German Primate Center Göttingen, Germany)
Using Brain Organoids to Reveal the Roles of ZNF90 and OVOL2 in Hominid Brain Development and Evolution
15:15 - 15:35 T03: Christin Struffert (University Hospital Muenster, Germany)
Convergent Mechanisms of Risk Genes in Psychiatric Disorders: A Functional Genomic and Drug Screening Approach
15:35 - 16:00
Coffee break
16:00 - 17:50
Session 2: Neurosensory
16:00 - 16:50 Keynote 2: Botond Roska (Basel, Switzerland)
A new therapeutic modality for eye diseases
16:50 - 17:10 T0:4: Kerstin Nagel-Wolfrum (Johannes Gutenberg University Mainz, Germany)
Single-cell analysis reveals impaired Müller glia-mediated intercellular
communication in USH1C retinal organoids
17:10 - 17:30 T05: Maria Pavlou (Center for Regenerative Therapies TU Dresden, Germany)
Transplanted hiPSC-derived photoreceptors differentially survive and mature in host mice with mild and severe retinal degeneration
17:30 - 17:45 S01: Anastasiia Tourbier (MaxWell Biosystems AG)
High-Density Microelectrode Arrays for Functional Insight into iPSC-Derived Models
17:45 - 17:50 Lightning Talks: Katerina Apostolidi; Lucia Occhigrossi; Clemens Sauter; Rebeka Stelcz; Zeynep Yentür
17:50 - 19:20
Poster Session 1
Odd numbers
19:30 - 21:30
Reception
Alte Aula, Münzgasse 30, 72070 Tübingen
09:00 - 10:25
Session 3: Neurodegeneration I
09:00 - 09:50 Keynote 3: Julia TCW (Boston, USA)
Deciphering functional mechanisms of Alzheimer's risk APOE4 using iPSC, human brains and chimeric models
09:00 - 10:10 T06: Sascha Koppes-den Hertog (Vrije Universiteit Amsterdam, The Netherlands)
Cholesterol regulates astrocyte reactivity and is dysregulated by ApoE4
10:10 - 10:25 S02: Mitzy Rios de Anda (bit.bio)
An in vitro tool kit to study complex cellular interactions in the CNS during physiological and pathological conditions
10:25 - 10:55
Coffee break
10:55 - 12:05
Session 3: Neurodegeneration I
10:55 - 11:15 T07: Virginia Cora (Maastricht University, The Netherlands)
Modelling human midbrain aging: an iPSC-based platform to explore senescence and age-related neurodegenerative disorders
11:15 - 11:35 T08: Jacob Helm (DZNE Tübingen, Germany)
SNP-guided targeting strategy in spinocerebellar ataxia type 3 using allele-specific antisense oligonucleotides
11:35 - 11:50 S03: Katharina Debowski (STEMCELL Technologies)
Rapid Generation of Functional Forebrain Neurons from Human Pluripotent Stem Cells Using a Novel NGN2 mRNA-LNP Platform
11:50 - 12:05 S04: Markus Uhrig (OLS OMNI Life Science)
Reliable 3D Cell Models High-Yield Cultivation Meets Precision Sorting
12:05 - 13:00
Lunch break
13:00 - 14:30
Workshops (parallel)
(W1) Basic Principles of science communication
Markus Gottschling (University of Tübingen, Germany)
(W2) Planning my next step – Career development inside/ outside academia
Silke Thul, Sabrina Lehner (DZNE Bonn, Germany)
(W3) Technology Transfer Trivia
Patrick Wunderlich, Dennis de Coninck (DZNE Bonn, Germany)
(W4) Organoid Intelligence
Alina Wernick (University of Tübingen) and Miriam Klopotek (University of
Stuttgart)
14:30 - 15:00
Coffee break
15:00 - 16:55
Session 4: Neuroglia
15:00 - 15:50 Keynote 4: Elly Hol (Utrecht, The Netherlands)
Human iPSC-derived models to study astrocytes in disease
15:50 - 16:10 T09: Taisia Rolova (University of Helsinki, Finland)
Inflammation-induced lysosomal dysfunction in human iPSC-derived
microglia is exacerbated by APOE 4/4 genotype
16:10 - 16:30 T10: Vanessa Donega (Amsterdam UMC, The Netherlands)
Disease and age-dependent effects on microglia in the subventricular zone of the human brain
16:30 - 16:50 T11: Weronika Tomaszewska (Research Network Łukasiewicz, Poland)
Interplay of serum lipids and microglia in the susceptibility to the long-term behavioral effects of adverse childhood experiences
16:50 - 16:55 Lightning Talks: Stefanie Fruhwürth; Gianluca Morganti; Marc Oudart; Helena Pivoňková; Karan Sharma
16:55 - 18:30
Poster session 2
Even numbers
19:30
Conference Dinner
upon invitation only
09:00 - 10:30
Session 5: Neurodegeneration II
09:00 - 09:50 Keynote 5: Anna Williams (Edinburgh, UK)
Understanding heterogeneity to help CNS neurodegenerative disorders
09:50 - 10:10 T12: Ines Elbini (Institut Pasteur De Tunis, Tunisia)
Venom peptides targeting Kv1.3 channels reduce alpha-synuclein
aggregation in stem cell models of Parkinson’s disease
10:10 - 10:30 T13: Jan Raska (Masaryk University Brno, Czech Republic)
SORLA-associated Alzheimer’s disease modelling in iPSC-Derived Neurons and Cerebral Organoids
10:30 - 11:00
Coffee break
11:00 - 11:50
Session 6: Emerging Technologies
11:00 - 11:50 Keynote 6: Martin Kampmann (San Francisco, USA)
Unbiased CRISPR screens to uncover mechanisms of brain function and disease
11:50 - 12:10 T14: Linus Wiora (DZNE Tübingen, Germany)
Transcriptional Silencing of AAV in Human iPSC-Derived Neural Cells Is
Overcome by Blocking Host SUMOylation
12:10 - 12:30 T15: Sven Fengler (DZNE Bonn, Germany)
Automated iPSC differentiation for High-Content Microphysiological Systems
12:30 - 12:50 T16: Peter Jones (NMI Reutlingen, Germany)
Electrophysiology inside neural spheroids using mesh microelectrode arrays
12:50 - 14:00
Wrap-up & lunch
Workshops
These workshops provide training in essential “soft skills” and encourage critical thinking and discussion.
Keynote Speakers
Infos about our keynote speakers: They all utilize stem cells to investigate neurosciece, from development to neurodegeneration and beyond.